The Best Tranquilizer

The best tranquilizers should meet the following requirements:

  1. Reduce anxiety 
  2. Tolerant 
  3. Should not have side effects 
  4. Should not be addictive 
  5. Can be taken over prolonged periods

Benzodiazepines is one of the most powerful tranquilizers. But their adverse effects such as dependency and possible memory loss have restricted their use to only serious cases and only for a short period of time.

It is interesting that natural plants have been used in laboratory for many years to develop the best chemical compounds contained in most medicines. Some plants have important anxiolytic properties and are better because they do not cause memory loss or dependency even when used over longer periods of time.

One of the natural herbs is passiflora (passionflower), whose efficacy some clinical studies have compared to benzodiazepines because it has very similar effects but without memory loss problems or dependence (See reference 1).

Interestingly, we can add certain herbs to boost its anxiolytic and tranquilizing effects so that it can even resolve some problems associated with anxiety such as irritable bowel syndrome (IBS) and chest pain (See reference 2).

Melissa (lemon balm) enhances the anxiolytic effects of passiflora. It acts as a potent inhibitor of GABA transaminase, which explains its anxiolytic effects (See reference 3). Melissa has also been known to improve mood and mental performance. These effects are believed to involve muscarinic and nicotinic acetylcholine receptors (See reference 4). It also acts as an antispasmodic, reducing bloating and flatulence symptoms that are common in people with irritable bowel síndrome (IBS).

Common Hawthorn exhibits a mild sedative activity in the brain similar to pasiflora and melissa. It also increases blood flow in coronary arteries and regulates the heart rate. It is also known to reduce palpitations caused by anxiety and nervousness. Its protective activity is due to its inhibition at 3´-5´-AMPc diesterase NaK-ATP ase and thromboxane synthesis (See reference 5).

An anxious person has a wear of nerve system cells (neurons and glia). Because of this, it is not advisable to only reduce the symptoms of anxiety, but also to recover the damage in the nervous cells. This can be achieved by taking vitamins B1, B6 and B12. These are neurotropic vitamins that enhance the regeneration of nerve cells. They are necessary for synthesizing mood boosting neurotransmitters, such as serotonin.

You have probably used Neurobion or Neurobionta at some point in life. It is used in the treatment of neuritis, neuralgia, lumbar syndrome, and even stress. This medication contains B1, B6 and B12 which constitute substances essential for the nerve cells metabolism which maintains the structural and functional properties of the nervous system.

Simply put, the combination of passiflora, melissa and common harthow integrally manages anxiety states and its major problems such as irritable bowel syndrome and chest pains. Taking vitamins B1, B6 and B12 for nerve cell protection could also be equated to taking the best tranquilizer.


  1. Akhondzadeh S, Naghavi HR, Vazirian M, et al. Passionflower in the treatment of generalized anxiety: a pilot double-blind randomized controlled trial with oxazepam. J Clin Pharm Ther . 2001;26:363-367.
  2. Speroni E, Minghetti A. Neuropharmacological activity of extracts from Passiflora incarnata.Planta Med. 1988;54:488 – 491.
  3. Kennedy, D. O.; Little, W; Scholey, AB (2004). “Attenuation of Laboratory-Induced Stress in Humans After Acute Administration of Melissa officinalis (Lemon Balm)”. Psychosomatic Medicine 66 (4): 607–13
  4. Kennedy, D O; Wake, G; Savelev, S; Tildesley, N T J; Perry, E K; Wesnes, K A; Scholey, A B (2003). “Modulation of Mood and Cognitive Performance Following Acute Administration of Single Doses of Melissa Officinalis (Lemon Balm) with Human CNS Nicotinic and Muscarinic Receptor-Binding Properties”. Neuropsychopharmacology 28 (10): 1871–81
  5. Chatterjee SS,et al . In vitro and in vivo studies on the cardioprotective action of oligomeric procyanidins in a Crataegus extract of leaves and blooms. Arzneimittelforschung 1997; 47(7):821-5.